Octreotide acetate
产品说明书
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同义名 : | SMS 201-995 acetate |
| CAS号 : | 79517-01-4 | |
| 货号 : | A589099 | |
| 分子式 : | C51H70N10O12S2 | |
| 纯度 : | 99% | |
| 分子量 : | 1079.29 | |
| MDL号 : | MFCD00871400 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(231.63 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 25 mg/mL(23.16 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently. Octreotide-treated groups show a significant reduction in the tumor volume when compared with saline group. Octreotide-PPSG (1.4 mg/kg, i.p.) shows greater antitumor effect than Octreotide-soln (100 μg/kg, i.p.). Octreotide-treatments results in significant inhibitory effect on the expression levels of SSTR2 and SSTR5 in primary HCC-bearing rats compared with the saline group[3]. Octreotide can decrease the rate of postoperative complication after pancreatic resection by diminishing exocrine function of the pancreas. Prophylactic octreotide is not effective to inhibit the exocrine secretion of the remnant pancreas and does not decrease the incidence of pancreatic fistula after pancreaticoduodenectomy[4]. The prophylactic use of LAO (long-acting octreotide acetate) did not prevent the incidence or reduce the severity of diarrhea and had no notable impact on patient-reported bowel function or QoL(quality of life)[5]. Octreotide LAR (octreotide acetate) 20 mg shows significant efficacy in terms of objective response rate (PR + SD), biochemical and symptomatic control in patients with metastatic NETs (neuroendocrine tumors) of the GEP system pretreated and progressing on slow release lanreotide[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00274170 | Migraine Headache | Phase 1 Phase 2 | Unknown | - | United States, Texas ... 展开 >> CR Darnall Army Medical Center Recruiting Ft. Hood, Texas, United States, 76544 收起 << |
| NCT00616551 | Acromegaly | Phase 3 | Completed | - | Belarus ... 展开 >> Republican Centre for Medical Rehabilitation and Water-therapy Minsk, Belarus Hungary Semmelweis Egyetem Általános Orvostudományi Budapest, Hungary Romania Institute of Endocrinology "C. I. Parhon" Bucharest Bucharest, Romania Serbia Institute of Endocrinology, University Clinical Center Belgrade, Serbia Slovakia Fakultná Nemocnica s Poliklinkou Bratislava Bratislava, Slovakia Ukraine V.P. Komisarenko Institute of Endocrinology and Metabolism, AMS Ukraine Kiev, Ukraine 收起 << |
| NCT00003057 | Colorectal Cancer ... 展开 >> Diarrhea 收起 << | Phase 3 | Completed | - | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
0.93mL 0.19mL 0.09mL |
4.63mL 0.93mL 0.46mL |
9.27mL 1.85mL 0.93mL |
| 参考文献 |
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