TTP 22

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Chemical Structure| 329907-28-0 同义名 : -
CAS号 : 329907-28-0
货号 : A586763
分子式 : C16H14N2O2S2
纯度 : 98%+
分子量 : 330.42
MDL号 : MFCD02654497
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(151.32 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • CK2

    CK2, IC50:100 nM
描述 Protein kinase CK2 (formerly known as casein kinase 2) is a constitutively-active kinase that is expressed ubiquitously in eukaryotes. CK2 is critical in embryonic development, differentiation, immunity, cell survival, epithelial homeostasis and circadian rhythms and is abnormally elevated in many cancers[2]. TTP 22 is a potent and ATP-competitive CK2 inhibitor, with an IC50 of 100 nM and a Ki of 40 nM. It shows selectivity for CK2 over other kianses such as Jnk3, Rock1, Tie2, Ask1, Met and FGFR1 at 10 μM[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.03mL

0.61mL

0.30mL

15.13mL

3.03mL

1.51mL

30.26mL

6.05mL

3.03mL
参考文献

[1]Golub AG, Bdzhola VG, et al. Synthesis and biological evaluation of substituted(thieno[2,3-d] pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur J Med Chem. 2011 Mar;46(3):870-6.

[2]Silva-Pavez E, Tapia JC. Protein Kinase CK2 in Cancer Energetics. Front Oncol. 2020 Jun 18;10:893

[3]Golub AG, Bdzhola VG, et al. Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur J Med Chem. 2011 Mar;46(3):870-6