Inauhzin

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Chemical Structure| 309271-94-1 同义名 : INZ
CAS号 : 309271-94-1
货号 : A586304
分子式 : C25H19N5OS2
纯度 : 99%+
分子量 : 469.58
MDL号 : MFCD01819836
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(223.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • SIRT1
描述 Inauhzin at a concentration of 10 µM elevates p53 levels comparably to actinomycin D at 10 nM and promotes p53-dependent cytotoxicity via its distinct functional groups in human lung carcinoma H460 cells. A lower concentration of Inauhzin (2 µM) enhances both the level and activity of p53, along with initiating p53-dependent apoptosis. It stabilizes p53, prevents its ubiquitylation, and increases p53 acetylation in H460 cells, specifically without affecting tubulin. This acetylation is impacted by the knockdown of SIRT1[1]. At doses up to 2 µM, Inauhzin markedly boosts the expression and activity of p53 in both HCT116p53+/+ and H460 cells in a dose-responsive manner. When combined with Nutlin-3, Inauhzin displays synergistic cytotoxic effects, particularly in cells with low sensitivity to Nutlin-3, and jointly they trigger p53-dependent apoptosis[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.65mL

2.13mL

1.06mL

21.30mL

4.26mL

2.13mL
参考文献

[1]Zhang Q, et al. A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO Mol Med. 2012 Apr;4(4):298-312.

[2]Zhang Y, et al. Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth. Cancer Biol Ther. 2012 Aug;13(10):915-24.