TAME

产品说明书

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Chemical Structure| 901-47-3 同义名 : N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯
CAS号 : 901-47-3
货号 : A586015
分子式 : C14H22N4O4S
纯度 : 98+%
分子量 : 342.41
MDL号 : MFCD01320524
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(306.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • APC

  • E3 Ligase
描述 TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.92mL

0.58mL

0.29mL

14.60mL

2.92mL

1.46mL

29.20mL

5.84mL

2.92mL
参考文献

[1]Zeng X, Sigoillot F, et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19;18(4):382-95.

[2]Ma Y, Lu G. Differential effects of Mg(ii) and N(alpha)-4-tosyl-l-arginine methyl ester hydrochloride on the recognition and catalysis in ATP hydrolysis. Dalton Trans. 2008 Feb 28;(8):1081-6.