Ruxolitinib (S enantiomer)

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Chemical Structure| 941685-37-6 同义名 : S-INCB18424; S-Ruxolitinib; (S)-INCB018424; INCB018424
CAS号 : 941685-37-6
货号 : A579847
分子式 : C17H18N6
纯度 : 98%
分子量 : 306.37
MDL号 : MFCD13184797
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(342.73 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

1M HCl: 50 mg/mL(163.2 mM)，配合低频超声，并调节pH至1
生物活性
靶点

  • JAK1

    JAK1, IC50:3.3 nM

  • Tyk2

    TYK2, IC50:19 nM

  • JAK2

    JAK2, IC50:2.8 nM
描述 Ruxolitinib (S enantiomer) (S-Ruxolitinib) is an orally active, potent JAK inhibitor that is the S-enantiomer of Ruxolitinib[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.26mL

0.65mL

0.33mL

16.32mL

3.26mL

1.63mL

32.64mL

6.53mL

3.26mL
参考文献

[1]Hye Kyung Lee, et al. JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells. Commun Biol. 2021 Jun 2;4(1):654.

[2]Lorena Arranz, et al. Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms. Nature. 2014 Aug 7;512(7512):78-81.