BMS-509744

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Chemical Structure| 439575-02-7 同义名 : -
CAS号 : 439575-02-7
货号 : A578447
分子式 : C32H41N5O4S2
纯度 : 98+%
分子量 : 623.83
MDL号 : MFCD18782598
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 20 mg/mL(32.06 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 BMS-509744 is a potent and selective Itk kinase inhibitor with an IC50 value of 19 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.02mL

1.60mL

0.80mL

16.03mL

3.21mL

1.60mL
参考文献

[1]Dondorf S, Schrader A, et al. Interleukin-2-inducible T-cell kinase (ITK) targeting by BMS-509744 does not affect cell viability in T-cell prolymphocytic leukemia (T-PLL). J Biol Chem. 2015 Apr 17;290(16):10568-9.

[2]Lin TA, McIntyre KW, et al. Selective Itk inhibitors block T-cell activation and murine lung inflammation. Biochemistry. 2004 Aug 31;43(34):11056-62.