Rocaglamide

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Chemical Structure| 84573-16-0 同义名 : Roc-A; NSC 326408; Rocaglamide A; MG-002
CAS号 : 84573-16-0
货号 : A570023
分子式 : C29H31NO7
纯度 : 99%+
分子量 : 505.56
MDL号 : MFCD08702699
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(207.69 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Rocaglamide (Roc-A), sourced from the Aglaia genus, is utilized for various ailments like coughs, injuries, asthma, and inflammatory skin disorders. It is a potent inhibitor of NF-κB activation in T-cells, a significant and selective suppressor of heat shock factor 1 (HSF1) activation with an IC50 value close to 50 nM, restricts the function of the translation initiation factor eIF4A, and exhibits anticancer effects, particularly against leukemia[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.98mL

0.40mL

0.20mL

9.89mL

1.98mL

0.99mL

19.78mL

3.96mL

1.98mL
参考文献

[1]Santagata S, et al. Tight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state. Science. 2013 Jul 19; 341(6143): 1238303.

[2]Luan Z, et al. Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation. Mol Med Rep

[3]Baumann B, et al. Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells. J Biol Chem. 2002 Nov 22;277(47):44791-800.