7-Chlorokynurenic Acid

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Chemical Structure| 18000-24-3 同义名 : -
CAS号 : 18000-24-3
货号 : A569101
分子式 : C10H6ClNO3
纯度 : 98%
分子量 : 223.61
MDL号 : MFCD00674924
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 15 mg/mL(67.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor, with an IC50 of 0.56 μM. It is also a strong inhibitor of glutamate reuptake into synaptic vesicles, with a Ki of 0.59 μM. Additionally, 7-CKA has demonstrated powerful antinociceptive effects following neuraxial administration[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.47mL

0.89mL

0.45mL

22.36mL

4.47mL

2.24mL

44.72mL

8.94mL

4.47mL
参考文献

[1]Kemp JA, et al. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6547-50.

[2]Yaksh TL, et al. Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents. J Pain. 2017 Oct;18(10):1184-1196.

[3]Croucher MJ, et al. 7-Chlorokynurenic acid, a strychnine-insensitive glycine receptor antagonist, inhibits limbic seizurekindling. Neurosci Lett. 1990 Oct 2;118(1):29-32.