Tofogliflozin (hydrate)

产品说明书

Print
Chemical Structure| 1201913-82-7 同义名 : CSG-452 hydrate; CSG 452; Tofogliflozin; Tofogliflozin hydrate
CAS号 : 1201913-82-7
货号 : A566836
分子式 : C22H28O7
纯度 : 99%+
分子量 : 404.45
MDL号 : MFCD28385880
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(259.61 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • SGLT2

    hSGLT2, IC50:2.9 nM
描述 Tofogliflozin is a potent and highly specific sodium/glucose cotransporter 2(SGLT2) inhibitor with Ki values of 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.36mL

2.47mL

1.24mL

24.72mL

4.94mL

2.47mL
参考文献

[1]Nagata T, Fukuzawa T, et al. Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function in db/db mice. Br J Pharmacol. 2013 Oct;170(3):519-31.

[2]Suzuki M, Honda K, et al. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.