Sisomicin Sulfate

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Chemical Structure| 53179-09-2 同义名 : 硫酸西索紫苏 ;Sisomicin(sulfate)
CAS号 : 53179-09-2
货号 : A558121
分子式 : C38H84N10O34S5
纯度 : ≥580 μg/mg
分子量 : 1385.45
MDL号 : MFCD00210364
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 120 mg/mL(86.61 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Sisomicin (Sulfate) is a new antibiotic produced by Micromonospora inyoensis. Sisomicin was significantly more active than tobramycin against Serratia and indole-positive Proteus strains. Sisomicin was significantly more active than gentamicin against indole-negative Proteus strains and slightly more active against indole-positive Proteus strains. The presence of 50% human serum did not antagonize the in vitro activity of sisomicin against gram-negative isolates [2]. Moreover, the nephrotoxicity of sisomicin or gentamicin involves chiefly the cortex, increases with the length of the treatment and can persist for several weeks after the last injection[3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00202891 Pyoderma Phase 4 Withdrawn(No further local int... 展开 >>erest in pursuing the study.) 收起 << - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.72mL

0.14mL

0.07mL

3.61mL

0.72mL

0.36mL

7.22mL

1.44mL

0.72mL
参考文献

[1]Rodriquez Torres A. [Sisomicin sulfate: its efficacy in the treatment of urologic infections] . Arch Esp Urol. 1979 Jul-Aug;32(4):387-96. Spanish.

[2]Crowe CC, Sanders E. Sisomicin: evaluation in vitro and comparison with gentamicin and tobramycin. Antimicrob Agents Chemother. 1973;3(1):24–28

[3]Fabre J, Rudhardt M, Blanchard P, Regamey C. Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats. Kidney Int. 1976;10(6):444–449