Netarsudil HCl

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Chemical Structure| 1253952-02-1 同义名 : AR-13324 hydrochloride; Netarsudil 2HCl
CAS号 : 1253952-02-1
货号 : A552197
分子式 : C28H29Cl2N3O3
纯度 : 99%+
分子量 : 526.45
MDL号 : MFCD29472289
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(7.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • ROCK

    ROCK, Ki:2 nM
描述 Netarsudil hydrochloride (AR-13324 hydrochloride) serves as an inhibitor for both Rho-associated protein kinase (ROCK) and the norepinephrine transporter (NET). It has demonstrated efficacy in lowering intraocular pressure (IOP)[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.50mL

1.90mL

0.95mL

19.00mL

3.80mL

1.90mL
参考文献

[1]Wang RF, et al. Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-54.

[2]Kiel JW, et al. Effect of AR-13324 on episcleral venous pressure in Dutch belted rabbits. J Ocul Pharmacol Ther. 2015 Apr;31(3):146-151.