INT-777

产品说明书

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Chemical Structure| 1199796-29-6 同义名 : S-EMCA
CAS号 : 1199796-29-6
货号 : A551476
分子式 : C27H46O5
纯度 : 99%+
分子量 : 450.65
MDL号 : MFCD18837028
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(66.57 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 45 mg/mL(99.86 mM)，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 INT-777 is a potent and selective TGR5 agonist with remarkable in vivo activity (EC50=0.82 μM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.10mL

2.22mL

1.11mL

22.19mL

4.44mL

2.22mL
参考文献

[1]Pellicciari R, Gioiello A, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.

[2]Thomas C, Gioiello A, et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009 Sep;10(3):167-77.