OTSSP167 HCl

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Chemical Structure| 1431698-10-0 同义名 : OTS167 hydrochloride; OTSSP167 (hydrochloride); OTSSP167 hydrochloride
CAS号 : 1431698-10-0
货号 : A550147
分子式 : C25H29Cl3N4O2
纯度 : 98%
分子量 : 523.88
MDL号 : MFCD25562907
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(66.81 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 7 mg/mL(13.36 mM)，配合低频超声助溶
生物活性
描述 OTSSP167 hydrochloride is a highly potent MELK inhibitor (IC50 = 0.41 nM) and inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.91mL

0.38mL

0.19mL

9.54mL

1.91mL

0.95mL

19.09mL

3.82mL

1.91mL
参考文献

[1]Ji W, Arnst C, et al. OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases. PLoS One. 2016 Apr 15;11(4):e0153518.

[2]Chung S, Suzuki H, et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. 2012 Dec;3(12):1629-40.