Etidronic acid

产品说明书

Print
Chemical Structure| 2809-21-4 同义名 : 羟基乙叉二膦酸;羟乙磷酸;1-羟基亚乙基-1,1-二膦酸 ;Etidronate; HEDPA; HEDP
CAS号 : 2809-21-4
货号 : A542632
分子式 : C2H8O7P2
纯度 : 98%
分子量 : 206.03
MDL号 : MFCD00070585
存储条件:

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(509.64 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(485.37 mM),配合低频超声助溶

生物活性
描述 Etidronic acid is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.85mL

0.97mL

0.49mL

24.27mL

4.85mL

2.43mL

48.54mL

9.71mL

4.85mL

参考文献

[1]Kawabata A, Kawao N, et al. Antiallodynic effect of etidronate, a bisphosphonate, in rats with adjuvant-induced arthritis: involvement of ATP-sensitive K+ channels. Neuropharmacology. 2006 Aug;51(2):182-90.

[2]Hiroi-Furuya E, Kameda T, et al. Etidronate (EHDP) inhibits osteoclastic-bone resorption, promotes apoptosis and disrupts actin rings in isolate-mature osteoclasts. Calcif Tissue Int. 1999 Mar;64(3):219-23.