Droperidol
产品说明书
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同义名 : | 氟哌利多 ;Dehydrobenzperidol; DHBP; Taylor Brand of Droperidol; Kern Brand of Droperidol; Janssen Brand of Droperidol; Properidol; Dridol; Inapsine; Droleptan; NSC 169874 |
| CAS号 : | 548-73-2 | |
| 货号 : | A541340 | |
| 分子式 : | C22H22FN3O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 379.43 | |
| MDL号 : | MFCD00083290 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 35 mg/mL(92.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Droperidol, a dopamine-2 receptor antagonist, is a butyrophenone, with anti-emetic, sedative and anti-anxiety properties. Parenteral droperidol is an effective option for the treatment of acute migraine. The minimum effective dose is 2.5 mg given IM or IV (intramuscularly or intravenously ). The most commonly reported adverse effects were extrapyramidal symptoms and sedation[3]. QT prolongation is noted with multiple medication classes, and droperidol increases QT interval in a dose-dependent fashion among susceptible individuals[4]. Midazolam-droperidol combination therapy is superior, in the doses studied, to either droperidol or olanzapine monotherapy for intravenous sedation of the acutely agitated ED (emergency department) patient[5]. Droperidol significantly reduced opioid-induced PONV (postoperative nausea and vomiting) in adults during PCA (patient-controlled analgesia) and had a morphine-sparing effect. Droperidol is generally well tolerated and the incidence of adverse effects is similar to that observed with placebo and the serotonin 5-HT3 receptor antagonists (setrons)[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03506789 | Postoperative Pain | Phase 4 | Recruiting | June 30, 2020 | Denmark ... 展开 >> Gildhøj Privathospital Not yet recruiting Brøndbyvester, Denmark, 2605 Contact: Niels A Pedersen, MD Bispebjerg Hospital Recruiting Copenhagen, Denmark, 2400 Contact: Troels H Lunn, DMSc Sjællands Universitetshospital, Køge Not yet recruiting Køge, Denmark, 4600 Contact: Ole Mathiesen, MD, PhD, Assoc Prof. Næstsved Sygehus Recruiting Næstved, Denmark, 4700 Contact: Kasper S Gasbjerg, MD Odense Universitetshospital Not yet recruiting Odense, Denmark, 5000 Contact: Søren Overgaard, DMSc 收起 << |
| NCT03618082 | Immediate Severe Postoperative... 展开 >> Pain Perioperative Hemodynamic 收起 << | Phase 3 | Not yet recruiting | March 31, 2021 | France ... 展开 >> CHU Clermont-Ferrand Not yet recruiting Clermont-Ferrand, Auvergne, France, 63003 Contact: Lise LACLAUTRE 04 73 75 49 63 drci@chu-clermontferrand.fr Principal Investigator: Jean-Etienne BAZIN Sub-Investigator: Bernard ALLAOUICHE Sub-Investigator: Emmanuel FUTIER Sub-Investigator: Lionel BOUVET Sub-Investigator: Régis FUZIER Sub-Investigator: Elizabeth GAERTNER Sub-Investigator: Mathieu JEANNE Sub-Investigator: Hervé MUSELLEC 收起 << |
| NCT03036514 | Pain, Postoperative | Not Applicable | Active, not recruiting | February 2019 | Belgium ... 展开 >> University hospital Antwerp Edegem, Antwerp, Belgium, 2650 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.64mL 0.53mL 0.26mL |
13.18mL 2.64mL 1.32mL |
26.36mL 5.27mL 2.64mL |
| 参考文献 |
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