Bupivacaine HCl

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Chemical Structure| 18010-40-7 同义名 : Bupivacaine (hydrochloride); (±)-1-butyl-2′,6′-Pipecoloxylidide; AH 2250; Bupivacaine hydrochloride
CAS号 : 18010-40-7
货号 : A540958
分子式 : C18H29ClN2O
纯度 : 99+%
分子量 : 324.89
MDL号 : MFCD00078956
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
靶点

  • Sodium Channel
描述 Bupivacaine has a strong affinity for SCN5A channels with an IC50 of 69.5 µM, making it valuable for chronic pain research[1].[2].[3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02679560 Femoral Fractures Phase 2 Recruiting April 2019 United States, California ... 展开 >> University of California Davis Med Center- Emergency Department Recruiting Sacramento, California, United States, 95817 Contact: Ian Brown, MD    916-734-1279    iebrown@ucdavis.edu 收起 <<
NCT02287623 Acute Pain Phase 4 Completed - -
NCT01429584 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.08mL

0.62mL

0.31mL

15.39mL

3.08mL

1.54mL

30.78mL

6.16mL

3.08mL
参考文献

[1]Casati A, et, al. Bupivacaine, levobupivacaine and ropivacaine: are they clinically different? Best Pract Res Clin Anaesthesiol. 2005 Jun;19(2):247-68.

[2]Dan J, et, al. Inhibition of gastric cancer by local anesthetic bupivacaine through multiple mechanisms independent of sodium channel blockade. Biomed Pharmacother. 2018 Jul;103:823-828.

[3]Carsten Stoetzer, et al. Inhibition of Voltage-Gated Na+ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine. Reg Anesth Pain Med.Jul/Aug 2017;42(4):462-468.