Gemifloxacin Mesylate
产品说明书
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同义名 : | LB-20304a; SB-265805S; Gemifloxacin (mesylate); LB20304 mesylate; SB265805 mesylate |
| CAS号 : | 210353-53-0 | |
| 货号 : | A538822 | |
| 分子式 : | C19H24FN5O7S | |
| 纯度 : | 99%+ | |
| 分子量 : | 485.49 | |
| MDL号 : | MFCD08277637 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(216.28 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(102.99 mM)，配合低频超声助溶 |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Gemifloxacin mesylate (GFM) is a synthetic broad-spectrum antibacterial agent[1]. Gemifloxacin is a fluoroquinolone antibacterial agent which has an enhanced affinity for topoisomerase IV. It has potent activity against most gram-positive bacteria, particularly streptococcus pneumoniae. Gemifloxacin is over 30-fold more active than ciprofloxacin and 4- to 8-fold more active than moxifloxacin against this pathogen. Gemifloxacin has excellent activity against Haemophilus influenzae and Moraxella catarrhalis, and is unaffected by beta-lactamase production. Atypical respiratory pathogens (Legionella, Mycoplasma and Chlamydia spp.) are highly susceptible to gemifloxacin. Oral gemifloxacin 320 mg/day produced bacteriological responses of 94.7% in patients with acute exacerbations of chronic bronchitis and 95% of patients with uncomplicated urinary tract infections[3]. DTH (Delayed type hypersensitivity) assay has shown the significant immune suppressant potential of gemifloxacin at 25 mg/kg dose and 75mg/kg dose in mice[4]. Gemifloxacin is microbiologically the most active fluoroquinolone against Streptococcus pneumoniae--the leading pathogen of CAP (community-acquired pneumonia)[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03535558 | - | Recruiting | December 31, 2018 | United States, New Jersey ... 展开 >> Janssen Investigative Site Recruiting Titusville, New Jersey, United States, 08560 收起 << | |
| NCT03479736 | - | Completed | - | United States, New Jersey ... 展开 >> Janssen Investigative Site Titusville, New Jersey, United States, 08560 收起 << | |
| NCT01881438 | - | Completed | - | - | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.06mL 0.41mL 0.21mL |
10.30mL 2.06mL 1.03mL |
20.60mL 4.12mL 2.06mL |
| 参考文献 |
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[3]Lowe MN, Lamb HM. Gemifloxacin. Drugs. 2000;59(5):1137‐1148 |