D-Sphingosine
产品说明书
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同义名 : | 鞘氨醇 ;Erythrosphingosine; trans-4-Sphingenine; Sphingosine (d18:1); D-erythro-Sphingosine C-18; Sphingosine, C18 chain; (2S,3R)-D-erythro-2-amino-1,3-Octadec-4E-enediol; Sphingosine; erythro-C18-Sphingosine; D-erythro-Sphingosine |
| CAS号 : | 123-78-4 | |
| 货号 : | A536742 | |
| 分子式 : | C18H37NO2 | |
| 纯度 : | 98% | |
| 分子量 : | 299.49 | |
| MDL号 : | MFCD00036751 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(166.95 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Protein kinase C, a family of related serine/threonine kinases implicated in multiple signal transduction pathways, exhibits antitumor property in mammalian cells. D-erythro-Sphingosine is a PKC inhibitor with an EC50 value of 8 ± 3 μM for p32. Treatment of Jurkat T cells with D-erythro-Sphingosine led to a ~4-fold increase in p32 phosphorylation, with the maximal effect observed at 10 μM[1]. D-erythro-Sphingosine is also a PP2A agonist that activates PP2A in neuronal cultures at a concentration of 10 nM. Rats treated with D-erythro-Sphingosine (1 μM) showed a higher locomotor BBB score after spinal cord injury compared to the vehicle-treated control group[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.34mL 0.67mL 0.33mL |
16.70mL 3.34mL 1.67mL |
33.39mL 6.68mL 3.34mL |
| 参考文献 |
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