VUF10166

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Chemical Structure| 155584-74-0 同义名 : -
CAS号 : 155584-74-0
货号 : A536132
分子式 : C13H15ClN4
纯度 : 99%+
分子量 : 262.74
MDL号 : MFCD01127814
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(399.64 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • 5-HT3

    5-HT3AB, Ki:22 nM

    5-HT3A, Ki:0.04 nM
描述 VUF10166, a high-affinity and potent antagonist of the 5-HT3 receptor, exhibits Ki values of 0.04 nM for 5-HT3A and 22 nM for 5-HT3AB. It effectively blocks responses induced by 5-HT at both 5-HT3A and 5-HT3AB receptors at nanomolar levels. Additionally, VUF10166 serves as a partial agonist at the 5-HT3 receptor at elevated concentrations, with an EC50 value of 5.2 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.81mL

0.76mL

0.38mL

19.03mL

3.81mL

1.90mL

38.06mL

7.61mL

3.81mL
参考文献

[1]Thompson AJ, et al. VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors. J Pharmacol Exp Ther. 2012 May;341(2):350-9.