LDN-27219

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Chemical Structure| 312946-37-5 同义名 : -
CAS号 : 312946-37-5
货号 : A529002
分子式 : C20H16N4O2S2
纯度 : 99+%
分子量 : 408.49
MDL号 : MFCD01943209
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(257.04 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 LDN-27219 is a potent inhibitor of hTGase (Tissue transglutaminase) with an IC50 of 0.6 μM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.45mL

0.49mL

0.24mL

12.24mL

2.45mL

1.22mL

24.48mL

4.90mL

2.45mL
参考文献

[1]Prime ME, Andersen OA, et al. Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J Med Chem.

[2]Case A, Stein RL. Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor. Biochemistry. 2007 Jan 30;46(4):1106-15.