NNK

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Chemical Structure| 64091-91-4 同义名 : -
CAS号 : 64091-91-4
货号 : A522339
分子式 : C10H13N3O2
纯度 : 98%
分子量 : 207.23
MDL号 : MFCD00274580
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(289.53 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 NNK, a nitrosated derivative of nicotine, concurrently induces phosphorylation of Bcl2 uniquely at Ser70 and c-Myc at Thr58 and Ser62 via activation of both ERK1/2 and PKCα[1]. NNK promotes the survival and proliferation of human lung cancer cells and can be utilized in constructing lung cancer mouse models[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.83mL

0.97mL

0.48mL

24.13mL

4.83mL

2.41mL

48.26mL

9.65mL

4.83mL
参考文献

[1]Jin Z, et al. Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. J Biol Chem. 2004;279(38):40209-40219.

[2]Castonguay A, et al. Lung tumorigenicity of NNK given orally to A/J mice: its application to chemopreventive efficacy studies. Exp Lung Res. 1991;17(2):485-499.

[3]Razani-Boroujerdi S, Sopori ML. Early manifestations of NNK-induced lung cancer: role of lung immunity in tumor susceptibility. Am J Respir Cell Mol Biol. 2007 Jan;36(1):13-9.