Triamterene

产品说明书

Print
Chemical Structure| 396-01-0 同义名 : NSC 77625; SKF8542; Diurene; Diucelpin; BRN 0266723; 2,4,7-Triamino-6-phenylpteridine
CAS号 : 396-01-0
货号 : A521542
分子式 : C12H11N7
纯度 : 98%
分子量 : 253.26
MDL号 : MFCD00006708
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(63.18 mM)，配合低频超声，并调节pH至5，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Sodium Channel

    ENaC, IC50:4.5 μM
描述 Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00000620 Atherosclerosis ... 展开 >> Cardiovascular Diseases Hypercholesterolemia Hypertension Diabetes Mellitus, Type 2 Diabetes Mellitus Coronary Disease 收起 << Phase 3 Completed - United States, Minnesota ... 展开 >> Minneapolis Medical Research Foundation Minneapolis, Minnesota, United States, 55404 United States, New York Columbia University New York, New York, United States, 10027 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27106 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Tennessee Veterans Affairs Memphis, Tennessee, United States, 38104 United States, Washington University of Washington Seattle, Washington, United States, 98195 Canada, Ontario McMaster University Hamilton, Ontario, Canada 收起 <<
NCT00000620 - Completed - -
NCT00684489 Hypertension Not Applicable Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.95mL

0.79mL

0.39mL

19.74mL

3.95mL

1.97mL

39.49mL

7.90mL

3.95mL
参考文献

[1]Fuhr U, Kober S, et al. Rate-limiting biotransformation of triamterene is mediated by CYP1A2. Int J Clin Pharmacol Ther. 2005 Jul;43(7):327-34.

[2]Busch AE, Suessbrich H, et al. Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis. Pflugers Arch. 1996 Sep;432(5):760-6.