Plecanatide

产品说明书

Print
Chemical Structure| 467426-54-6 同义名 : -
CAS号 : 467426-54-6
货号 : A517907
分子式 : C65H104N18O26S4
纯度 : 99+%
分子量 : 1681.89
MDL号 : MFCD33029246
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(62.43 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Plecanatide is an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, it is approved in January 2017 by the FDA for the treatment of chronic idiopathic constipation (CIC).
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02387359 Irritable Bowel Syndrome Chara... 展开 >>cterized by Constipation 收起 << Phase 3 Completed - -
NCT01722318 Irritable Bowel Syndrome Chara... 展开 >>cterized by Constipation 收起 << Phase 2 Completed - -
NCT02493452 Irritable Bowel Syndrome Chara... 展开 >>cterized by Constipation 收起 << Phase 3 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.59mL

0.12mL

0.06mL

2.97mL

0.59mL

0.30mL

5.95mL

1.19mL

0.59mL
参考文献

[1]Shailubhai K, Comiskey S, et al. Plecanatide, an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, is safe and well-tolerated in single doses. Dig Dis Sci. 2013;58(9):2580-6.