TCS7010

产品说明书

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Chemical Structure| 1158838-45-9 同义名 : Aurora A Inhibitor I
CAS号 : 1158838-45-9
货号 : A517880
分子式 : C31H31ClFN7O2
纯度 : 99%+
分子量 : 588.08
MDL号 : MFCD16495816
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(85.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Aurora A

    Aurora A, IC50:3.4 nM
描述 TCS7010 is an exceptionally selective inhibitor of Aurora A kinases, distinguishing itself by not inhibiting Aurora B. This specificity makes TCS7010 a valuable tool compound for studying the specific cellular roles of Aurora A kinases without the confounding effects of Aurora B inhibition[1].
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
HCT116 cells Proliferation assay 4 days Antiproliferative activity against human HCT116 cells after 4 days by celltiter assay, IC50=0.19 μM 19402633
HT-29 cells Proliferation assay 4 days Antiproliferative activity against human HT-29 cells after 4 days by celltiter assay, IC50=2.9 μM 19402633
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.70mL

0.34mL

0.17mL

8.50mL

1.70mL

0.85mL

17.00mL

3.40mL

1.70mL
参考文献

[1]Aliagas-Martin I, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Huang OW, Hunsaker T, Kleinheinz T, Krueger E, Liang J, Moffat J, Phillips G, Pulk R, Rawson TE, Ultsch M, Walker L, Wiesmann C, Zhang B, Zhu BY, Cochran AG.A class of 2,4-bisanilinopy