Pyridostatin HCl

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Chemical Structure| 1781882-65-2 同义名 : RR82 hydrochloride; Pyridostatin hydrochloride
CAS号 : 1781882-65-2
货号 : A516623
分子式 : C31H37Cl5N8O5
纯度 : 99%
分子量 : 778.94
MDL号 : N/A
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 50 mg/mL(64.19 mM)，配合低频超声助溶
生物活性
描述 Pyridostatin hydrochloride is a G-quadruplex-interacting drug which can promote growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.28mL

0.26mL

0.13mL

6.42mL

1.28mL

0.64mL

12.84mL

2.57mL

1.28mL
参考文献

[1]Rodriguez R, Miller KM, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012 Feb 5;8(3):301-10.

[2]Koirala D, Dhakal S, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011 Aug 28;3(10):782-7.