Swertiamarin

产品说明书

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Chemical Structure| 17388-39-5 同义名 : 獐牙菜苦甙 ;Swertiamarine
CAS号 : 17388-39-5
货号 : A513464
分子式 : C16H22O10
纯度 : 99%+
分子量 : 374.34
MDL号 : MFCD07783984
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(667.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Swertiamarin, a natural product isolated and purified from the herbs of Swertia bimaculata, possesses anti-hyperglycemic, anti-hyperlipidemic, anti-diabetic activity and enhances β cell regeneration which causes reversal of diabetes.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.36mL

2.67mL

1.34mL

26.71mL

5.34mL

2.67mL
参考文献

[1]Dhanavathy G. Immunohistochemistry, histopathology, and biomarker studies of swertiamarin, a secoiridoid glycoside, prevents and protects streptozotocin-induced β-cell damage in Wistar rat pancreas. J Endocrinol Invest. 2015 Jun;38(6):669-84.

[2]Sonawane RD, Deore VB, et al. Role of 5-HT2 receptors in diabetes: Swertiamarin seco-iridoid glycoside might be a possible 5-HT2 receptor modulator. Physiol Behav. 2015 May 15;144:66-72.