BIX02189

产品说明书

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Chemical Structure| 1265916-41-3 同义名 : -
CAS号 : 1265916-41-3
货号 : A511821
分子式 : C27H28N4O2
纯度 : 99%+
分子量 : 440.54
MDL号 : MFCD18074528
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(113.5 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 BIX02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.35mL

2.27mL

1.13mL

22.70mL

4.54mL

2.27mL
参考文献

[1]Obara Y, Nemoto W, et al. Basic fibroblast growth factor promotes glial cell-derived neurotrophic factor gene expression mediated by activation of ERK5 in rat C6 glioma cells. Cell Signal. 2011 Apr;23(4):666-72.

[2]Tatake RJ, O'Neill MM, et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5.