CVT-10216

产品说明书

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Chemical Structure| 1005334-57-5 同义名 : GS-455534
CAS号 : 1005334-57-5
货号 : A511113
分子式 : C24H19NO7S
纯度 : 95%
分子量 : 465.48
MDL号 : MFCD18072197
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:1个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(38.67 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

DMF: 25 mg/mL(53.71 mM)，配合低频超声助溶
生物活性
描述 CVT-10216 is a highly selective, reversible inhibitor of aldehyde dehydrogenase-2 (ALDH-2) with an IC50 of 29 nM. Additionally, CVT-10216 exhibits inhibitory effects on ALDH-1 with an IC50 of 1.3 μM. CVT-10216 has demonstrated the ability to decrease excessive alcohol consumption in alcohol-preferring rats and to show anxiolytic effects [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.21mL

10.74mL

2.15mL

1.07mL

21.48mL

4.30mL

2.15mL
参考文献

[1]Overstreet DH, et al. A selective ALDH-2 inhibitor reduces anxiety in rats.Pharmacol Biochem Behav. 2009 Dec;94(2):255-61.