SB 271046 HCl

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Chemical Structure| 209481-24-3 同义名 : SB 271046A; SB-271046 (hydrochloride); SB 271046 Hydrochloride
CAS号 : 209481-24-3
货号 : A505828
分子式 : C20H23Cl2N3O3S2
纯度 : 99%+
分子量 : 488.45
MDL号 : MFCD10565914
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(102.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(2.05 mM)，配合低频超声，并水浴加热至45℃助溶
生物活性
靶点

  • 5-HT6

    5-HT6, pKi:8.92
描述 SB 271046 Hydrochloride (SB 271046A) is a potent, selective, and orally active antagonist of the 5-HT6 receptor with pKi values of 9.02, 8.55, and 8.81 for rat, pig, and human, respectively. It shows over 200-fold selectivity for the 5-HT6 receptor compared to 55 other receptors, binding sites, and ion channels and exhibits anticonvulsant activity with an EC50 of 0.16 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.05mL

0.41mL

0.20mL

10.24mL

2.05mL

1.02mL

20.47mL

4.09mL

2.05mL
参考文献

[1]Routledge C, et al. Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist. Br J Pharmacol. 2000;130(7):1606-1612.