Riviciclib HCl

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Chemical Structure| 920113-03-7 同义名 : P276-00; Riviciclib hydrochloride
CAS号 : 920113-03-7
货号 : A505118
分子式 : C21H21Cl2NO5
纯度 : 98%
分子量 : 438.3
MDL号 : MFCD26960898
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(114.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 25 mg/mL(57.04 mM)，配合低频超声助溶
生物活性
靶点

  • CDK4

    CDK4/CyclinD1, IC50:63 nM

  • CDK2

    CDK2/CyclinA, IC50:224 nM

    CDK2/CyclinE, IC50:2.54 μM

  • CDK6

    CDK6/CyclinD3, IC50:396 nM

  • CDK9

    CDK9/CyclinT1, IC50:20 nM
描述 P276-00 is a CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.28mL

0.46mL

0.23mL

11.41mL

2.28mL

1.14mL

22.82mL

4.56mL

2.28mL
参考文献

[1]Joshi KS, Rathos MJ, et al. In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00. Mol Cancer Ther. 2007 Mar;6(3):918-25.

[2]Joshi KS, Rathos MJ, et al. P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. Mol Cancer Ther. 2007 Mar;6(3):926-34.