CNX-774

产品说明书

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Chemical Structure| 1202759-32-7 同义名 : -
CAS号 : 1202759-32-7
货号 : A503177
分子式 : C26H22FN7O3
纯度 : 99%+
分子量 : 499.5
MDL号 : MFCD26405992
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 45 mg/mL(90.09 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • BTK

    BTK, IC50:<1 nM
描述 CNX-774, an orally active, irreversible, and selective BTK inhibitor with an IC50 of <1 nM, specifically targets Cysteine 481 of Btk for covalent modification [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.00mL

0.40mL

0.20mL

10.01mL

2.00mL

1.00mL

20.02mL

4.00mL

2.00mL
参考文献

[1]Matthew Labenski, et al. In Vitro Reactivity Assessment of Covalent Drugs Targeting Bruton's Tyrosine Kinase.

[2]Akintunde Akinleye, et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol. 2013 Aug 19;6:59.