Clinafloxacin

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Chemical Structure| 105956-97-6 同义名 : CI-960; PD 127391; AM-1091
CAS号 : 105956-97-6
货号 : A498776
分子式 : C17H17ClFN3O3
纯度 : 99%
分子量 : 365.79
MDL号 : MFCD00865120
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(5.47 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Topo IV
描述 Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.73mL

0.55mL

0.27mL

13.67mL

2.73mL

1.37mL

27.34mL

5.47mL

2.73mL
参考文献

[1]Humphrey GH, Shapiro MA, et al. Pharmacokinetics of clinafloxacin enantiomers in humans. J Clin Pharmacol. 1999 Nov;39(11):1143-50.

[2]Pan XS, Fisher LM. DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob Agents Chemother. 1998 Nov;42(11):2810-6.