TCS 1102

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Chemical Structure| 916141-36-1 同义名 : -
CAS号 : 916141-36-1
货号 : A493447
分子式 : C27H26N4O2S
纯度 : 99%+
分子量 : 470.59
MDL号 : MFCD18086894
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(223.13 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.12mL

0.42mL

0.21mL

10.62mL

2.12mL

1.06mL

21.25mL

4.25mL

2.12mL
参考文献

[1]Chen X, Wang H, et al. Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks. Brain Struct Funct. 2014 Nov;219(6):2103-18.

[2]Bergman JM, Roecker AJ, et al. Proline bis-amides as potent dual orexin receptor antagonists. Bioorg Med Chem Lett.