HG-10-102-01

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Chemical Structure| 1351758-81-0 同义名 : -
CAS号 : 1351758-81-0
货号 : A488136
分子式 : C17H20ClN5O3
纯度 : 98%
分子量 : 377.83
MDL号 : MFCD28160565
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(132.34 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2 (IC50=23.3 nM) and the G2019S mutant (IC50=3.2 nM)
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.65mL

0.53mL

0.26mL

13.23mL

2.65mL

1.32mL

26.47mL

5.29mL

2.65mL
参考文献

[1]Choi HG, Zhang J, et al. Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 2012 Aug 9;3(8):658-662.

[2]Wang M, Gao M, et al. Synthesis of [(11)C] HG-10-102-01 as a new potential PET agent for imaging of LRRK2 enzyme in Parkinson's disease. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1351-1355.