Oxomemazine
产品说明书
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同义名 : | - |
| CAS号 : | 3689-50-7 | |
| 货号 : | A484536 | |
| 分子式 : | C18H22N2O2S | |
| 纯度 : | 97% | |
| 分子量 : | 330.44 | |
| MDL号 : | MFCD00868197 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(317.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Oxomemazine, a phenothiazine-based histamine H1-receptor antagonist, exhibits significant antimuscarinic effects. It acts as a selective antagonist for the muscarinic M1 receptor, demonstrating approximately a 20-fold difference in affinity between high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 μM, M2 receptor) affinity sites[1]. Oxomemazine, an antihistamine and anticholinergic agent, is employed for researching cough treatment[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.03mL 0.61mL 0.30mL |
15.13mL 3.03mL 1.51mL |
30.26mL 6.05mL 3.03mL |
| 参考文献 |
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