KIRA6

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Chemical Structure| 1589527-65-0 同义名 : IRE1 Inhibitor IV; IRE1α Kinase Inhibiting RNase Attenuator 6
CAS号 : 1589527-65-0
货号 : A483760
分子式 : C28H25F3N6O
纯度 : 97%
分子量 : 518.53
MDL号 : MFCD29477497
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(48.21 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 KIRA6 is highlighted as a sophisticated small-molecule inhibitor targeting the IRE1α RNase kinase, displaying an IC50 of 0.6 µM[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.93mL

0.39mL

0.19mL

9.64mL

1.93mL

0.96mL

19.29mL

3.86mL

1.93mL
参考文献

[1]Mahameed M,et al. The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors. Cell Death Dis. 2019 Apr 1;10(4):300.

[2]Ghosh R, et al. Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31;158(3):534-48.