PD 151746

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Chemical Structure| 179461-52-0 同义名 : -
CAS号 : 179461-52-0
货号 : A477369
分子式 : C11H8FNO2S
纯度 : 95%
分子量 : 237.25
MDL号 : MFCD03453564
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
靶点

  • Cysteine Protease

    m-calpain, IC50:5.33 μM

    μ-Calpain, IC50:260 nM
描述 PD151746 is a calpain inhibitor, shows a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.21mL

0.84mL

0.42mL

21.07mL

4.21mL

2.11mL

42.15mL

8.43mL

4.21mL
参考文献

[1]Porn-Ares MI, Saido TC, et al. Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells. Biochem J. 2003 Sep 1;374(Pt 2):403-11.

[2]Wang KK, Nath R, et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.