Phyllanthin

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Chemical Structure| 10351-88-9 同义名 : NSC 619043
CAS号 : 10351-88-9
货号 : A471856
分子式 : C24H34O6
纯度 : 95%
分子量 : 418.52
MDL号 : MFCD17166965
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(143.36 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Phyllanthin, a natural product isolated and purified from the herb of Phyllanthus niruri L., is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.39mL

0.48mL

0.24mL

11.95mL

2.39mL

1.19mL

23.89mL

4.78mL

2.39mL
参考文献

[1]Krithika R, Jyothilakshmi V, Verma RJ. Phyllanthin inhibits CCl4-mediated oxidative stress and hepatic fibrosis by down-regulating TNF-α/NF-κB, and pro-fibrotic factor TGF-β1 mediating inflammatory signaling. Toxicol Ind Health. 2016 May;32(5):953-60.

[2]Sukhaphirom N, Vardhanabhuti N, et al. Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells. J Pharm Pharmacol. 2013 Feb;65(2):292-9.