Vicriviroc maleate

产品说明书

Print
Chemical Structure| 599179-03-0 同义名 : SCH-D maleate; SCH-417690 maleate; SCH 417690; Vicriviroc (maleate)
CAS号 : 599179-03-0
货号 : A461706
分子式 : C32H42F3N5O6
纯度 : 95%
分子量 : 649.7
MDL号 : MFCD09833218
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(76.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 25 mg/mL(38.48 mM)
生物活性
靶点

  • HIV Protease
描述 Vicriviroc maleate is a CCR5 antagonist with IC50 of 0.91 nM in clinical development for the treatment of HIV-1.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00551330 HIV Infections ... 展开 >> Acquired Immunodeficiency Syndrome 收起 << Phase 2 Completed - -
NCT00705419 - Completed - -
NCT00243230 HIV Infections Phase 2 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.54mL

0.31mL

0.15mL

7.70mL

1.54mL

0.77mL

15.39mL

3.08mL

1.54mL
参考文献

[1]Edward O'Mara, Claudia Kasserra, et al. Effect of Vicriviroc on the QT/Corrected QT Interval and Central Nervous System in Healthy Subjects. Antimicrob Agents Chemother. 2010; 54(6): 2448-2454.

[2]Sanjay B, Husam O, et al. Science Direct: Novel targets for anti-retroviral therapy. December 2009, Pages 377-386