Danegaptide HCl

产品说明书

Print
Chemical Structure| 943133-81-1 同义名 : GAP-134 Hydrochloride; ZP 1609 Hydrochloride; Danegaptide Hydrochloride
CAS号 : 943133-81-1
货号 : A458107
分子式 : C14H18ClN3O4
纯度 : 99%
分子量 : 327.76
MDL号 : MFCD23160032
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 55 mg/mL(167.8 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(152.55 mM)
生物活性
描述 GAP-134 hydrochloride, a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.31mL

15.26mL

3.05mL

1.53mL

30.51mL

6.10mL

3.05mL
参考文献

[1]De Vuyst E, Boengler K, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163(3):469-83.

[2]Laurent G, Leong-Poi H, et al. Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs. Circ Arrhythm Electrophysiol. 2009 Apr;2(2):171-8.