YO-01027

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Chemical Structure| 209984-56-5 同义名 : DBZ; Dibenzazepine; Deshydroxy LY-411575.; Iminostilbene
CAS号 : 209984-56-5
货号 : A457173
分子式 : C26H23F2N3O3
纯度 : 99%+
分子量 : 463.48
MDL号 : MFCD12828734
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 75 mg/mL(161.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 YO-01027 (Dibenzazepine) (GMP) is YO-01027 synthesized following Good Manufacturing Practice (GMP) standards. GMP-compliant small molecules serve effectively as ancillary agents in the production of cell therapies. YO-01027 acts as a potent inhibitor of γ-secretase [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.16mL

0.43mL

0.22mL

10.79mL

2.16mL

1.08mL

21.58mL

4.32mL

2.16mL
参考文献

[1]Groth C, et al. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Mol Pharmacol. 2010 Apr;77(4):567-74.

[2]Fuwa H, et al. Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. ACS Chem Biol. 2007 Jun 15;2(6):408-18.

[3]Wu J, et al. Dibenzazepine promotes cochlear supporting cell proliferation and hair cell regeneration in neonatal mice. Cell Prolif. 2020 Sep;53(9):e12872.

[4]Xiao Z, et al. The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation. Int J Biochem Cell Biol. 2014 Oct;55:65-71.