Tizanidine

产品说明书

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Chemical Structure| 51322-75-9 同义名 : -
CAS号 : 51322-75-9
货号 : A456347
分子式 : C9H8ClN5S
纯度 : 99%
分子量 : 253.71
MDL号 : MFCD00865192
存储条件:

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 20 mg/mL(78.83 mM),配合低频超声,并调节pH至3,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02403687 - Completed - -
NCT01753882 Spinal Cord Injury Phase 1 Unknown July 2017 United States, Illinois ... 展开 >> Rehabilitation Institute of Chicago Chicago, Illinois, United States, 60611 收起 <<
NCT01547234 - Completed - Israel ... 展开 >> Multiple Sclerosis Center Carmel Medical Center Haifa, Israel 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.94mL

0.79mL

0.39mL

19.71mL

3.94mL

1.97mL

39.42mL

7.88mL

3.94mL

参考文献

[1]Yazicioğlu D, Caparlar C, et al. Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial. Eur J Anaesthesiol. 2016 Mar;33(3):215-22.

[2]Locuson CW, Williams P, et al. Evaluation of tizanidine as a marker of canine CYP1A2 activity. J Vet Pharmacol Ther. 2016 Apr;39(2):122-30.