S1RA
产品说明书
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同义名 : | E-52862 |
| CAS号 : | 878141-96-9 | |
| 货号 : | A451689 | |
| 分子式 : | C20H23N3O2 | |
| 纯度 : | 99% | |
| 分子量 : | 337.42 | |
| MDL号 : | MFCD25976945 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 35 mg/mL(103.73 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 1M HCl: 50 mg/mL(148.19 mM)，配合低频超声，并调节pH至1 |
| 生物活性 | |||
|---|---|---|---|
| 描述 | S1RA (E-52862) is a highly selective σ1 receptor (σ1R) antagonist with Kis of 17 nM and 23.5 nM for human σ1R and guinea pig σ1R, respectively. Its activity extends moderately towards the human 5-HT2B receptor with a Ki of 328 nM. This selectivity profile is complemented by its antinociceptive capabilities in models of neuropathic pain, demonstrating efficacy in preventing both mechanical and cold hypersensitivity in mice treated with Oxaliplatin[1][2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.96mL 0.59mL 0.30mL |
14.82mL 2.96mL 1.48mL |
29.64mL 5.93mL 2.96mL |
| 参考文献 |
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