PCI 29732

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Chemical Structure| 330786-25-9 同义名 : -
CAS号 : 330786-25-9
货号 : A447708
分子式 : C22H21N5O
纯度 : 99%
分子量 : 371.44
MDL号 : MFCD25976874
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(134.61 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 8 mg/mL(21.54 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 PCI 29732 serves as a highly effective, orally bioavailable, and reversible inhibitor of BTK, displaying Kiapp values of 8.2 nM for BTK, 4.6 nM for Lck, and 2.5 nM for Lyn. Its inhibitory effect on Itk, another member of the Tec family kinases, is relatively modest. Moreover, PCI 29732 disrupts the activity of ABCG2 by competitively attaching to its ATP-binding site[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.46mL

2.69mL

1.35mL

26.92mL

5.38mL

2.69mL
参考文献

[1]Pan Z, et al. Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. ChemMedChem. 2007 Jan;2(1):58-61.

[2]Ge C, et al. PCI29732, a Bruton's Tyrosine Kinase Inhibitor, Enhanced the Efficacy of Conventional Chemotherapeutic Agents in ABCG2-Overexpressing Cancer Cells. Cell Physiol Biochem. 2018;48(6):2302-2317.

[3]Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010;107(29):13075-13080.