Sulfaclozine

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Chemical Structure| 102-65-8 同义名 : Sulfachloropyrazine; Sulfalozine sodium; Sulfachlopryrazine sodium; Sulfaclozine sodium
CAS号 : 102-65-8
货号 : A447526
分子式 : C10H9ClN4O2S
纯度 : 98%
分子量 : 284.72
MDL号 : MFCD00868569
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(105.37 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Sulfaclozine is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections[3]. Sulfaclozine and fluoroquinolones were mainly detected in chicken samples, and sulfamethazine was mainly detected in pork samples. High levels of sulfonamide residues, ranging between 2500 and 2700 μg/kg sulfaclozine and between 1300 and 3600 μg/kg sulfamethazine, were present in two chicken and three pork samples, respectively[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.51mL

0.70mL

0.35mL

17.56mL

3.51mL

1.76mL

35.12mL

7.02mL

3.51mL
参考文献

[1]Sheridan R, Mirabile J, Hafler K. Determination of six illegal antibiotics in chicken jerky dog treats. J Agric Food Chem. 2014 Apr 30;62(17):3690-6.

[2]Sentepe I, Eraslan G. Pharmacokinetic of sulfaclozine in broiler chickens. Food Chem Toxicol. 2010 Jan;48(1):448-51.

[3]Sentepe I, Eraslan G. Pharmacokinetic of sulfaclozine in broiler chickens. Food Chem Toxicol. 2010;48(1):448–451

[4]Yamaguchi T, Okihashi M, Harada K, et al. Antibiotic residue monitoring results for pork, chicken, and beef samples in Vietnam in 2012-2013. J Agric Food Chem. 2015;63(21):5141–5145