Benzamide

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Chemical Structure| 55-21-0 同义名 : Benzenecarboxamide; Phenylamide
CAS号 : 55-21-0
货号 : A446394
分子式 : C7H7NO
纯度 : 98%
分子量 : 121.14
MDL号 : MFCD00007968
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 115 mg/mL(949.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • PARP

    PARP, IC50:3.3 μM
描述 Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature. Benzamide (160 mg/kg; IP, 2 injection by a 4 h interval) attenuates the METH-induced dopamine depletions. Benzamide (160 mg/kg; IP, single dosage) has no acute effect on striatal dopamine metabolism and does not reduce body temperature[3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01636947 Nausea Vomiti... 展开 >>ng 收起 << Phase 4 Completed - -
NCT01636947 - Completed - -
NCT00080444 Vomiting Phase 3 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

8.25mL

1.65mL

0.83mL

41.27mL

8.25mL

4.13mL

82.55mL

16.51mL

8.25mL
参考文献

[1]Wang XY, Lim-Jurado M, et al. Treatment of allergic rhinitis and urticaria: a review of the newest antihistamine drug bilastine. Ther Clin Risk Manag. 2016 Apr 13;12:585-97.

[2]Kun E, Kirsten E, et al. Cell cycle-dependent intervention by benzamide of carcinogen-induced neoplastic transformation and in vitro poly(ADP-tibosyl)ation of nuclear proteins in human fibroblasts. Proc Natl Acad Sci U S A. 1983 Dec;80(23):7219-23.

[3]Cosi C, Chopin P, Marien M. Benzamide, an inhibitor of poly(ADP-ribose) polymerase, attenuates methamphetamine-induced dopamine neurotoxicity in the C57B1/6N mouse. Brain Res. 1996;735(2):343-348.