VS-5584

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Chemical Structure| 1246560-33-7 同义名 : SB2343
CAS号 : 1246560-33-7
货号 : A444142
分子式 : C17H22N8O
纯度 : 98%
分子量 : 354.41
MDL号 : MFCD25372027
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(98.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • p110γ

    PI3Kγ, IC50:3.0 nM

  • p110β

    PI3Kβ, IC50:21 nM

  • p110α

    PI3Kα, IC50:2.6 nM

  • p110δ

    PI3Kδ, IC50:2.7 nM
描述 VS-5584 is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.82mL

0.56mL

0.28mL

14.11mL

2.82mL

1.41mL

28.22mL

5.64mL

2.82mL
参考文献

[1]Shao Z, Bao Q, et al. VS-5584, a Novel PI3K-mTOR Dual Inhibitor, Inhibits Melanoma Cell Growth In Vitro and In Vivo. PLoS One. 2015 Jul 23;10(7):e0132655.

[2]Hart S, Novotny-Diermayr V, et al. VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Mol Cancer Ther. 2013 Feb;12(2):151-61.