α-Vitamin E

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Chemical Structure| 59-02-9 同义名 : 天然维生素E ;D-α-Tocopherol; (+)-α-Tocopherol; Mixed tocopherols; D-alpha tocopherol; alpha-Tocopherol; Vitamin E
CAS号 : 59-02-9
货号 : A443508
分子式 : C29H50O2
纯度 : 98%
分子量 : 430.71
MDL号 : MFCD00072045
存储条件:

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(243.79 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(232.18 mM),配合低频超声助溶,注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇

动物实验配方:
生物活性
描述 Vitamin E (VE) is considered a candidate anticancer drug. It has a significant antioxidant effect that prevents cardiovascular diseases, atherosclerosis, and cancer.VE has anti-inflammatory and antithrombolytic functions, and protects cell membranes. Using our Vitamin E-conjugated tumor-targeting compound revealed that the cellular uptake of 123I-1 increased in a time-dependent manner (3.48 ± 0.16, 3.59 ± 0.32, 4.26 ± 0.32, and 5.35 ± 0.54% at 1, 4, 16, and 24 h, respectively). In addition, HeLa cells were treated with 100 μM Vitamin E for 24 h,Vitamin E early-phase, 3.09%; late-phase apoptosis, 1.85%[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.32mL

0.46mL

0.23mL

11.61mL

2.32mL

1.16mL

23.22mL

4.64mL

2.32mL

参考文献

[1]Kang TH, Knoff J, et al. Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects. PLoS One. 2014 Jul 29;9(7):e103562.

[2]Yim MS, Soung NK, Han EH, Min JY, Han H, Son EJ, Kim HN, Kim B, Bang JK, Ryu EK. Vitamin E-Conjugated Phosphopeptide Inhibitor of the Polo-Box Domain of Polo-Like Kinase 1. Mol Pharm. 2019 Dec 2;16(12):4867-4877. doi: 10.1021/acs.molpharmaceut.9b00757. Epub 2019 Nov 11. PMID: 31663746.