LX-1031

产品说明书

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Chemical Structure| 945976-76-1 同义名 : -
CAS号 : 945976-76-1
货号 : A439308
分子式 : C28H25F3N4O4
纯度 : 98% HPLC
分子量 : 538.52
MDL号 : MFCD19443125
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(64.99 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 LX1031 is an oral, small molecule tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin(5-HT) synthesis peripherally.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.28mL

1.86mL

0.93mL

18.57mL

3.71mL

1.86mL
参考文献

[1]Brown PM, Drossman DA, et al. The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome. Gastroenterology. 2011 Aug;141(2):507-16.

[2]Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterol Motil. 2011 Mar;23(3):193-200.