Mps1-IN-1

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Chemical Structure| 1125593-20-5 同义名 : Monopolar Spindle 1 Kinase Inhibitor 1; Mps1 Kinase Inhibitor 1
CAS号 : 1125593-20-5
货号 : A437557
分子式 : C28H33N5O4S
纯度 : 97%
分子量 : 535.66
MDL号 : N/A
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(74.67 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Mps1-IN-1 is a highly potent and selectibe Mpsl inhibitor with IC50 of 367 nM, displaying > 1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.87mL

0.37mL

0.19mL

9.33mL

1.87mL

0.93mL

18.67mL

3.73mL

1.87mL
参考文献

[1]Kwiatkowski N, Jelluma N, et al. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol. 2010 May;6(5):359-68.